Bacteria often live in groups, called biofilms, where they cooperate and compete with each other using an extraordinarily diverse array of interactive phenotypes. These interactions are central to how bacteria evolve and how they impact the biotic and abiotic world around them. We use tools from ecology, evolution, microscopy, and molecular biology to understand the cell-scale mechanisms and biofilm-scale consequences of bacterial social interaction.
Spatial propagation of temperate phages within and among biofilms
Winans JB, Garcia SL, Zeng L, Nadell CD†. (2024). bioRxiv www.biorxiv.org/content/10.1101/2023.12.20.571119v4. (†corresponding)
Dispersal of a dominant competitor can drive multispecies coexistence in biofilms
Holt JD, Schultz D, Nadell CD†. (2024). Current Biology 34: 1-14 (†corresponding)
Wucher BR, Winans JB, Elsayed M, Kadouri DE, Nadell CD†. (2023). PNAS 120(6): e2212650120 (†corresponding)
– Feature journal cover and commentary by Thomas Platt
– Featured paper in episode #282 of This Week in Microbiology (TWiM – ASM offical podcast)
Multispecies biofilm architecture determines bacterial exposure to phages
Winans J, Wucher BR, Nadell CD†. (2022). PLoS Biology 20(12): e3001913 (†corresponding)
Social evolution of shared biofilm matrix components
Tai J-S B, Mukherjee S, Nero T, Olson R, Tithof J, Nadell CD†, Yan J†. (2022). PNAS 119(27): e2123469119. (†corresponding)
Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells
Bond MC, Vidakovic L, Singh PK, Drescher K, Nadell CD†. (2021). eLife 10: e65355 (†corresponding)
Kasetty S, Mould DL, Hogan DA, Nadell CD† (2021). mSphere 6(3): e00416-21 (†corresponding)
Bacterial predation transforms the landscape and community assembly of biofilms
Wucher BR, Elsayed M, Adelman JS, Kadouri KE, Nadell CD†(2021). Current Biology 31: 1-9 (†corresponding)
Simmons EL*, Bond MC*, Koskella B, Drescher K, Bucci V, Nadell CD†. (2020) mSystems 5(3): e00877-19 (*co-first authors; †corresponding)
Wucher BR, Bartlett TM, Hoyos M, Papenfort K, Persat A, Nadell CD†. (2019) PNAS 116(28): 14216-14221 (†corresponding)